That sounds like enough of an answer–it might be do-able, but it’s going to be hack-y and therefore probably fragile.
VMs are great for trying out software, but sometimes the software in question just isn’t designed for x64. Current example:
Of course, a Pi is cheap, but you don’t always have a spare lying around (or, in my present case, a spare power supply). It’d be nice to be able to load up a .img into a VM and see how it runs–doesn’t look like that’s going to be feasible though.