Onlyoffice and DYNDNS

I assume you need a valid certificate like letsencrypt.

You could try to use FQDN instead of IP like https://sub.domain.de/nextcloud/ instead of https://1.2.3.4/nextcloud.

Another way is to disable the certificate check (don’t know if it works for internal onlyoffice):

If it’s still not working you may try the external onlyoffice:

https://wiki.nethserver.org/doku.php?id=onlyoffice